Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
Im Buch
Ergebnisse 1-5 von 56
... therapeutic intervention (Kroemer and Pouyssegur 2008). For instance, Genistein, a natural isoflavonoid with several anti-tumour properties, induces both apoptosis and inhibition of tumour proliferation (Alhasan et al. 1999) ...
... type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim Biophys Acta 1555:14–20 Peng B, Hayes M, Resta D et al (2004) Pharmacokinetics 34 M. Bizzarri et al.
... Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer Res 66: 5477–5486 ter Kuile BH, Westerhoff HV (2001) Transcriptome meets metabolome: hierarchical and ...
... therapeutic environment such as the effects of a drug candidate in inhibiting these pathways. With the view that pathway simulation may contribute an effective way to investigate biological processes, this chapter studies the p53 ...
... therapeutic intervention for cancer treatment (Zilfou and Lowe 2009). 3. The. p53. Pathway. The p53 pathway is an integration of numerous genes and their products are targeted to respond to stress signals that potentially regulate cell ...
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |