Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
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... Approach to Study Cancer Related Pathways.......... Yike Guo and Xian Yang 3 Modeling Oncogenic Signaling Networks from Gene Expression Dynamics...........................................................................
... networks. Breast Dis 26:27–54 Hunt TK, Pai MP (1972) The effect of varying ambient oxygen tensions on wound ... signalling in skeletal muscle from Type 2 diabetic patients. Diabetologia 46:1324–1328 Kolch W, Calder M, Gilbert D (2005) When ...
... pathways. Science 292:504–507 Pierce GB, Nakane PK, Martinez-Hernandez A et al ... signaling pathway. J Biol Chem 277:35730–35737 Postovit LM, Margaryan NV ... networks: generating order from disorder through self-organization. Semin ...
... Network rigidity and metabolic engineering in metabolite overproduction ... networks: understanding metabolic complexity in the systems biology era. New ... signaling dependent and independent mechanisms. Cancer Res 66: 5477–5486 ter ...
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Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |