Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
Im Buch
Ergebnisse 1-5 von 85
... role in cancer resistance. Addressing this important area, Part III provides insights into important network evaluation methodologies related to microRNAs targetome and its relation to oncogenesis. Critical aspects of mRNA-microRNAs ...
... Role of TumorMicroenvironment Communication in Development, Progression and Therapy Resistance .................................................... Sara Chiblak, Fevzi Demircioglu, Azadeh Fahim Golestaneh, and Amir Abdollahi Part II ...
... a Specialized Role of MicroRNAs in Regulation of Oncogenesis.............................. 247 Jun-ichi Satoh 11 Novel and Alternative Bioinformatics Approaches to Understand miRNA-mRNA Interactome in Cancer Research ...
... role as a carbon source, glutamine also donates nitrogen to nucleotide and amino acid synthesis. Great arrows indicate the preferential directions to which cancer metabolism is committed. Abbreviations: P phosphate, GA3P glyceraldehydes ...
... role in carcinogenesis (Yin et al. 2004). On the other hand, disorders of the Krebs cycle activity predispose to hepatocellular carcinoma in human (Scheers et al. 2005), while rare inherited deficiencies of mitochondrial succinate ...
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |