Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
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... and readability which should appeal to the lay audience as well as to experts on multiple sides of the research bench or patient's bed. This unique book is comprised of 17 highly informative chapters vii. Preface. Preface.
... patients (Evans et al. 2005). Even if no specific gene defect responsible for insulin resistance and diabetes has been identified in humans, recent studies have shown that expression of genes involved in mitochondrial oxidative ...
... patients (Mootha et al. 2004). The efficiency of mitochondrial energy conversion might be a relevant factor in triggering the metabolic abnormalities observed in cancer cells (Modica-Napolitano and Singh 2002). The reduction in the ...
... patients. BMJ 330:1304–1305 Fantin VR, St-Pierre J, Leder P (2006) Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9:425–434 Fiehn O (2002) Metabolomics ...
... patients. Diabetologia 46:1324–1328 Kolch W, Calder M, Gilbert D (2005) When kinases meet mathematics: the systems biology of MAPK signaling. FEBS Lett579:1891–1895 Kondoh H, Lleonart ME, Gil J et al (2005) Glycolytic enzymes can ...
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |