Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
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... metastases. Another major area that is cementing its position in cancer research involves non-coding RNA or microRNAs. Computational models have also been applied to understand microRNAs biogenesis, regulation, and their role in cancer ...
... metastatic cancers, showing a direct correlation between tumour aggressiveness and the rate of glucose utilization (Kunkeletal. 2003). These results, even with some exceptions (Zu and Guppy 2004), outlined the clinical importance of ...
... metastatic spreading. However, such characteristics are not specific for cancer. Embryonic tissues (Seshagiri and Bavister 1991), as well as highly proliferating cells share a similar pattern, even if evolution has devised more than one ...
... Metastasis Rev 7:119–142 Hedeskov CJ (1968) Early effects of phytohaemagglutinin on glucose metabolism of normal human lymphocytes. Biochem J 110:373–380 Heinemann M, Sauer U (2010) Systems biology of microbial metabolism. Curr Opin ...
... metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60: 916–921 Wang T, Marquardt C, Foker J (1976) Aerobic glycolysis during lymphocyte proliferation. Nature 261:702–705 Warburg O (1926) ...
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |