Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
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Ergebnisse 1-5 von 45
... kinase GLUT-1 Glucose transporter PGK-1 Phosphoglycerate kinase NBE Normalized bending energy MCA Metabolic control analysis G6P Glucose 6 phosphate. 1. Why. Are. Metabolomics. Studies. so. Relevant. for. Cancer. Studies? In the first ...
... kinase signalling cascade (Le Mellay et al. 2002). However, similar alterations in growth factors of induced gene-expression have also been noticed in developing embryo cells or during wound healing (Riss et al. 2006). It is, therefore ...
... kinase (Bannasch et al. 1997b). The overall pattern of enzymatic changes observed in preneoplastic foci closely mimics the phenotypes of liver cells exposed to high insulin levels, but can be also found in other models of ...
... kinase, whereas over-expression of frataxin increases phosphorylation of p38 and reduces activation of a pro-proliferative MAP kinase such as ERK. Although the primary function of frataxin is still a matter of investigation, there is no ...
... kinase (PGK)-1, and vascular endothelial growth factor (VEGF) were similarly found to be increased in both neoplastic skin and wound edge (Elson et al. 2000). Undoubtedly, no mutations nor oncogene overexpression were needed to up ...
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |