Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
Im Buch
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... disease harboring uncountable variables. In order to make advancements in our understanding of cancer and to improve its management, there has to be a paradigm shift in research principles, even if that means crossing the boundaries of ...
... Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network....................... 289 Xia Li, Juan Xu, and Yongsheng Li Part IV Network Modeling in Cancer Drug Discovery and Clinical Trials 13 Development and ...
... disease, diabetes and several types of cancer (Salmerón et al. 1997; DeMeo 2001). The association is significantly evidenced only in human beings with elevated body mass index (>25 kg/m2) and/or with low physical activity, indicating an ...
... disease' characterized by impaired differentiation, as already outlined and documented by increasing experimental data (Soto et al. 2008; Cho et al. 2006; Ramalho-Santos et al. 2009). During both embryonic and fetal stages of ...
... disease. Nat Biotechnol 20:243–249 Castleman KR (1996) Digital image processing. Prentice-Hall, Englewood Cliffs Cho YM, Kwon S, Pak YK et al (2006) Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the ...
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |