Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
Im Buch
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... cellular lipids, requires acetyl-CoA (Ac-CoA), most of which is generated from glucose and transferred from the mitochondria to the cytoplasm via citrate. In addition to its role as a carbon source, glutamine also donates nitrogen to ...
... cellular macromolecules (DNA, proteins and lipids) under steady-state conditions can lead to oxidative damage if the antioxidant defences are not fully efficient. Hence, one can hypothesize that transition to aerobic glycolysis serves ...
... cellular disorder, and increased entropy, i.e., characteristics of cancer (Szent-Gyorgyi 1977). Therefore, changes in a metabolomic profile “precedes and underlies the genome instability that accompanies tumour development. Once ...
... cellular ATP depletion, such as fructose consumption (Terrier et al. 1989; Enzhmann et al. 1989), or to impaired expression of oxidative-phosphorylation-related genes, mainly associated with altered phosphorylation pattern of p38 MAP ...
... cellular representation of oxidative phosphorylation transcripts. Furthermore, hepatomas express isoforms of the glycolytic enzymes which are different from those present in adult liver, but similar to fetal isoforms (Pedersen 1978). It ...
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |