Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
Im Buch
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... VEGF) down-regulation and ROS increase (De Bels et al. 2011). Hence, “any unspecific condition that damages a cell's oxidative phosphorylation can potentially initiate the path to a malignant cancer. Some of the many unspecific ...
... (VEGF) were similarly found to be increased in both neoplastic skin and wound edge (Elson et al. 2000). Undoubtedly, no mutations nor oncogene overexpression were needed to up regulate the above mentioned changes in glycolytic-related ...
... (VEGF) and increased synthesis and release of collagen into the cell's microenvironment. Altogether, these effects may contribute to cancer initiation The glycolytic phenotype can be 'reversed' by appropriate manipulation of the ...
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Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |