Systems Biology in Cancer Research and Drug DiscoveryAsfar S Azmi Springer Science & Business Media, 29.09.2012 - 423 Seiten Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer. |
Im Buch
Ergebnisse 1-5 von 27
... Natl Acad Sci USA 71:50–51 Le Mellay V, Houben R, Troppmair J et al (2002) Regulation of glycolysis by Raf protein serine/ threonine kinases. Adv Enzyme Regul 42:317–332 Lee LM, Seftor EA, Bonde Get al (2005) The fate of human malignant ...
... Natl Acad Sci USA 101:6570–6575 Moreadith RW, Lehninger AL (1984) The pathways of glutamate and glutamine oxidation by tumour cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J Biol Chem 259:6215–6221 Mori M ...
... Natl Acad Sci USA 105:4329–4334 Pouyssegur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441:437–443 Price ND, Reed JL, Palsson BØ (2004) Genome-scale models of microbial ...
... Acad Sci 957:239–249 Seshagiri PB, Bavister BD (1991) Glucose and phosphate inhibit respiration and oxidative ... Natl Acad Sci USA 94:6658–6663 Shureiqi I, Lippman SM (2001) Lipoxygenase modulation to reverse carcinogenesis. Cancer Res ...
Du hast die Anzeigebeschränkung für dieses Buch erreicht.
Inhalt
Systems Approaches to Understand Cancer Progression | 165 |
Systems and Network Biology in Decoding miRNA Complexity | 246 |
Network Modeling in Cancer Drug Discovery and Clinical Trials | 307 |
Erratum | 418 |
Index | 419 |