Bioreaction Engineering: Modeling and Control
The book is intended to present various examples for reactor and process modeling and control as well as for metabolic flux analysis and metabolic design at an ad vanced level. In Part A, General principles and techniques with regard to reactor and process models, process control, and metabolic flux analysis are presented. In addition the accuracy, precision, and reliability of the measured data are discussed which are ex tremely important for process modeling and control. A virtual bioreactor system is presented as well, which can be used for the training of students and operators of industrial plants and for the development of advanced automation tools. In Part B, the General principles are applied for particular bioreactor models. It covers the application of the computational fluiddynamic (CFD) technique to stirred tank and bubble column bioreactors. Different solution methods are presented: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with an appropriate turbulence (k-ee) model, and the Euler (two fluid model), as well as the Euler-Langrange approaches.
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Accuracy and Reliability of Measured Data
Application of Computational Fluiddynamics CFD
Modeling of the Beer Fermentation Process
Control Strategies for HighCell Density Cultivation of Escherichia coli
ßLactam Antibiotics Production with Penicillium chrysogenum
Quantitative Analysis of Metabolic and Signaling Pathways
Illustrated for the Enzyme PFK1 Phosphofructokinase 1
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activity amino acids balance equations batch Biochem biomass bioprocess bioreactor Biotechnol Bioeng bubble column calculated carbon cell mass Chem Eng chemostat concentration considered constant culture dehydrogenase density described determined dilution rate dynamic energy enzyme estimation ethanol experimental data fed-batch feed fermentation flow fluid flux distribution fructose function gas phase glucose glucose 6-phosphate glutamate glutamicum glycolysis Graaf AA hyphae impeller increase inhibition intracellular isotope isotopomer kinetics labeling lactic acid limitation linear liquid phase lysine mass transfer maximum measurements metabolic flux metabolic flux analysis metabolite metabolite balancing microorganisms mobilis NADH NADPH on-line operation optimization oxaloacetate oxidative oxygen parameters pathway pellet Penicillin pentose phosphate pathway phosphate plasmid product formation protein pyruvate reaction rates reactor Sahm H segregated model simulation specific growth rate Stephanopoulos stirred tank stoichiometric structured substrate sugar synthesis temperature tion transport turbulent uptake rate variables vector velocity vivo