Bioreaction Engineering: Modeling and Control

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K. Schügerl, K.-H. Bellgardt
Springer Science & Business Media, 06.12.2012 - 604 Seiten
The book is intended to present various examples for reactor and process modeling and control as well as for metabolic flux analysis and metabolic design at an ad vanced level. In Part A, General principles and techniques with regard to reactor and process models, process control, and metabolic flux analysis are presented. In addition the accuracy, precision, and reliability of the measured data are discussed which are ex tremely important for process modeling and control. A virtual bioreactor system is presented as well, which can be used for the training of students and operators of industrial plants and for the development of advanced automation tools. In Part B, the General principles are applied for particular bioreactor models. It covers the application of the computational fluiddynamic (CFD) technique to stirred tank and bubble column bioreactors. Different solution methods are presented: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with an appropriate turbulence (k-ee) model, and the Euler (two fluid model), as well as the Euler-Langrange approaches.
 

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Inhalt

Introduction
1
References
17
Bioprocess Models
44
References
102
Accuracy and Reliability of Measured Data
125
Bioprocess Control
145
References
166
Application of Computational Fluiddynamics CFD
207
References
319
Modeling of the Beer Fermentation Process
321
References
347
Control Strategies for HighCell Density Cultivation of Escherichia coli
374
ßLactam Antibiotics Production with Penicillium chrysogenum
391
Quantitative Analysis of Metabolic and Signaling Pathways
434
Illustrated for the Enzyme PFK1 Phosphofructokinase 1
462
References
475

and Biotechnical Processes
232
References
244
Bakers Yeast Production
277
and Continuous Cultivations
291
Metabolic Flux Analysis of Corynebacterium glutamicum
506
Analysis of Metabolic Fluxes in Mammalian Cells
556
Subject Index
595
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