Chemical Warfare Toxicology: Volume 1: Fundamental AspectsDespite ongoing efforts to prohibit the production, storage and use of chemical warfare agents recent world events highlight the enduring threat to the population from these agents. Research efforts in various countries have resulted in novel insights into chemical warfare toxicology that has enabled the development of new approaches for the diagnosis and treatment of chemical warfare poisoning. This book provides an up-to-date treatise on the ongoing research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning. Focussing on the fundamentals of the toxicology of nerve agents and vesicants, this book will give the reader a comprehensive overview of the many different aspects of chemical warfare agent toxicology. The text will appeal to toxicologists, biochemists and weapons specialists working in industry and academia, and anyone with an interest in chemical warfare toxicology or exposure. |
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Inhalt
| 1 | |
| 29 | |
| 81 | |
Chapter 4 Toxicology and Treatment of Phosgene Induced Lung Injury | 117 |
Chapter 5 Human Exposures to Sulfur Mustard | 154 |
Chapter 6 LongTerm Effects of the Chemical Warfare Agent Sulfur Mustard | 179 |
Chapter 7 Toxicokinetics of Sulfur Mustard | 191 |
A Physiologically Based PharmacokineticPharmacodynamic PBPKPD Model of VX | 213 |
Chapter 9 Allometric Modeling of Mammalian Cyanogen Chloride Inhalation Lethality | 264 |
Subject Index | 307 |
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Chemical Warfare Toxicology: Volume 1: Fundamental Aspects Franz Worek,John Jenner,Horst Thiermann Eingeschränkte Leseprobe - 2016 |
Häufige Begriffe und Wortgruppen
acute adduct alkylation allometric animals Biochem blood flows brain aChe activity cancer cardiac output casualties cell Chemical Warfare Agents Chemical Weapons chlorine clinical concentration Cyanogen chloride cyclosarin damage decreased dermal described developed diaphragm dosing compartment endpoint erythema estimates exposed to SM eyes Figure hairless guinea pig human increased inhalation inhibition injection intravenous irritation lesions lethal levels Lewisite liquid marmoset metabolism mg kg−1 mg min m−3 mice miosis mouse mustard gas national archive number nerve agents oedema opCW parameters percutaneous perfused Pharmacol phosgene phosgene exposure poisoning probit produced pulmonary pulmonary oedema rabbit rats respiratory tract response route sarin simulation skin soman species studies sulfur mustard tabun thiodiglycol tion toxicity toxicokinetics Toxicol Toxicology treatment UK archive number UK national archive vapour vesicant vitro volatile volume vX kg−1 Bw WWii µg vX kg−1
