Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists

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Cambridge University Press, 04.09.2000 - 531 Seiten
A true understanding of genetic and metabolic function and design is facilitated by mathematical and computational methods for analyzing biochemical systems. This hands-on reference teaches biochemists and molecular biologists the use of modern computational methods for the analysis of complex biomedical systems requiring a modest mathematical background. The book begins with representations of biochemical systems, provides guidelines for setting up models, details mathematical and computational methods of parameter estimation and model analysis, and connects to the modern literature with four detailed case studies. Every step is illustrated with examples and explored with accompanying PLAS software. The volume also features over 250 exercises with about one quarter fully or partially solved.
 

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Inhalt

Graphical Representation of Biochemical Systems
11
Models of Biochemical Systems
37
From Maps to Equations
76
Computer Simulation
97
Parameter Estimation
143
Analytical SteadyState Evaluation
193
Sensitivity Analysis
222
Case Study 1 Anaerobic Fermentation Pathway in Saccharomyces cerevisiae
260
Case Study 3 A Sequence of Models Describing Purine Metabolism
326
Case Study 4 Algebraic Analysis of the Initial Steps of the GlycolyticGlycogenolytic Pathway in Perfused Rat Liver
365
Epilogue Canonical Modeling Beyond Biochemistry
399
Appendix
413
Hints and Partial Solutions
443
References
469
Author Index
499
Subject Index
507

Case Study 2 Diagnosis and Refinement of a Model of the Tricarboxylic Acid Cycle in Dictyostelium discoideum
293

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