New Frontiers of Network Analysis in Systems Biology

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Avi Ma'ayan, Ben D. MacArthur
Springer Science & Business Media, 25.06.2012 - 202 Seiten
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The rapidly developing field of systems biology is influencing many aspects of biological research and is expected to transform biomedicine. Some emerging offshoots and specialized branches in systems biology are receiving particular attention and are becoming highly active areas of research. This collection of invited reviews describes some of the latest cutting-edge experimental and computational advances in these emerging sub-fields of systems biology. In particular, this collection focuses on the study of mammalian embryonic stem cells; new technologies involving mass-spectrometry proteomics; single cell measurements; methods for modeling complex stochastic systems; network-based classification algorithms; and the revolutionary emerging field of systems pharmacology.
 

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Inhalt

Chapter 1 Gene Expression Profiling and Regulatory Networks in Single Cells
1
Chapter 2 Cell Fate Regulatory Networks
15
Chapter 3 Noise in Regulatory Networks
30
Chapter 4 Generalised Modelling in Systems Biology
59
Chapter 5 Relative Quantification Mass Spectrometry Using iTRAQ Isobaric Tags
77
Chapter 6 Deciphering Protein Complexes and Protein Interaction Networks for Stem Cell Pluripotency
96
Chapter 7 Omics Era in Stem Cell Research Data Integration of Multiregulatory Layers
119
Chapter 8 High Throughput Affinity Purification and Mass Spectrometry to Determine Protein Complex Interactions
139
Chapter 9 Network Pharmacology to Aid the Drug Discovery Process
160
Chapter 10 What Can Networks Do for You?
173
Index
195
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Über den Autor (2012)

Avi Ma’ayan, Ph.D., is an Assistant Professor in the Department of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine, New York, NY, USA. His interests are in applying graph theory, machine learning, dimensionality reduction, dynamical modeling, and visualization methods for integrating “omics” datasets collected from mammalian sources to better understand biological regulation on a global scale.

Ben D. MacArthur, Ph.D., is a Lecturer in Mathematics at the Life Science Interface in the Schools of Mathematics and Medicine at the University of Southampton, UK. His interests are in applying mathematical methods to problems in cell and molecular biology including modeling of cell fate, analysis of the structure and function of biological regulatory networks, and high throughput data analysis and bioinformatics.

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