The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.
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1 Prebiotic Chemistry on the Primitive Earth
Is a SystemLevel Understanding Feasible?
3 Shotgun Fragment Assembly
4 Gene Finding
5 Local Sequence Similarities
Reading and Comprehension
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Academy of Sciences affinity algorithm amino acids analysis annotation approach atmosphere bacterial base pairs binding sites biochemical Bioinformatics cells chemical clone coli complex computational database detection distance DNA sequence domain dynamic programming edges encoded enzymes eukaryotic evolutionary exons experimental figure fold function gene finders gene finding gene prediction genetic Genome Research genome sequence GENSCAN homologous horizontal gene transfer identify interactions introns Journal of Molecular k-mer length Markov models mate pair metabolic methods microRNA Molecular Biology Molecular Evolution molecules multiple National Academy networks noncoding RNAs Nucleic Acids Research nucleotide optimal ORFs organic compounds Orgel origin overlap graph pathways phylogenetic polymers prebiotic synthesis primitive Earth problem prokaryotic PROSPECTOR_3 protein sequence protein structure prediction protein-coding reaction regions regulatory repeat RMSD Sciences USA score sequence alignment signals similar Skolnick snoRNAs specificity splicing systems biology target sequence TASSER template tion transcription unique unitig unitig graph