Handbook of Research on Systems Biology Applications in Medicine

Cover
Daskalaki, Andriani
IGI Global, 30.11.2008 - 982 Seiten
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Systems biology is the study of the interactions between the components of a biological system and the way these interactions lead to a specific function and behavior of that system.

The Handbook of Research on Systems Biology Applications in Medicine presents concepts of the applications of systems biology in medicine, leading students and advanced researchers to an understanding of current ideas in the complex field of systems biology, analysis of data, and development of models, simulation, and drug development. With over 50 incisive research contributions from international experts, this unsurpassed compendium of critical research is an indispensable resource for medical libraries worldwide.

 

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Inhalt

Systems and Control Theory for Medical Systems Biology
11
Mathematical Description of Time Delays in Pathways Cross Talk
27
Deterministic Modeling in Medicine
74
Synthetic Biology as a Proof of Systems Biology
97
Computational Models for the Analysis of Modern Biological Data
117
Computer Aided Knowledge Discovery in Biomedicine
126
Phylogenetic Profiling
143
Computational Methods for the Prediction of GPCRs Coupling Selectivity
167
In Machina Systems for the Rational De Novo Peptide Design
438
Applications of Metabolic Flux Balancing in Medicine
458
MultiLevel Data Integration and Data Mining in Systems Biology
476
Methods for Reverse Engineering of Gene Regulatory Networks
497
Data Integration for Regulatory Gene Module Discovery
516
Discrete Networks as a Suitable Approach for the Analysis of Genetic Regulation
530
A Review of Signal Processing Approaches
541
Open Source Software for Population Analysis
556

A Common Structural Theme Implicated in a Wide Variety of Functional Roles
182
Clustering Methods for GeneExpression Data
209
Uncovering Fine Structure in Gene Expression Profile by Maximum Entropy Modeling of cDNA Microarray Images and Kernel Density Methods
221
Gene Expression Profiling with the BeadArray Platform
239
The Affymetrix GeneChip Microarray Platform
251
Alternative Isoform Detection Using Exon Arrays
262
Gene Expression in Microbial Systems for Growth and Metabolism
278
Alternative Splicing and Disease
291
Mathematical Modeling of the Aging Process
312
A Model of Hormonal Aging
331
Systems Biology Applied to Cancer Research
339
Systems Biology Strategies in Studies of Energy Homeostasis In Vivo
354
Approaching Type 2 Diabetes Mellitus by Systems Biology
361
Systems Biology and Infectious Diseases
377
Systems Biology of HumanPathogenic Fungi
403
Development of Specific Gamma Secretase Inhibitors
423
How Proteins Control Excitation Energy Transfer
573
A Systems Biology Approach
588
Modeling of Porphyrin Metabolism with PyBioS
643
Interference Microscopy for Cellular Studies
656
Fluorescence Imaging of Mitochondrial LongTerm Depolarization in Cancer Cells Exposed to HeatStress
673
Protein Interactions and Diseases
694
The Reactome Perspective
714
Entropy and Thermodynamics in Biomolecular Simulation
731
Model Development and Decomposition in Physiology
759
A Pandemic Avian Influenza Mathematical Model
798
A Mathematical Model with Immunization Program
809
Automated Image Analysis Approaches in Histopathology
About the Contributors
Index
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Über den Autor (2008)

Andriani Daskalaki presently works in the field of molecular medicine and bioinformatics at the Max Planck Institute for Molecular Genetics in Berlin. She completed her PhD in 2002 on working in the applications of photodynamic therapy in the area of oral medicine from the Free University of Berlin. She received a two-year DAAD scholarship (1996-1998) for her research in the field of PDT. Dr. Daskalaki received a MS in Medical Informatics from TFH Berlin with her work in “Development of a documentation software for robot-assisted intraoral operations” and a MS degree in bioinformatics with her work in “Variance analysis of multifactor models in gene expression experiments with application to the identification of genetic markers for hypertension.” She received a poster prize for her participation in the International Photodynamic Association Meeting in Nantes. She is the editor of the “Handbook of Research on Systems Biology Applications in Medicine” and has presented many oral presentations at national and international meetings. She is a founding member and committee member of the Greek Dental Laser Association. Her research interest areas include systems biology, PDT, and laser applications in dentistry. [Editor]

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