Jens Nielsen, Stefan Hohmann, Sang Yup Lee, Gregory Stephanopoulos
John Wiley & Sons, 30.05.2017 - 432 Seiten
Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems.
Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression.
This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.
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13C Flux Analysis in Biotechnology and Medicine
Metabolic Modeling for Design of Cell Factories
GenomeScale Metabolic Modeling and Insilico Strain Design
Accelerating the Drug Development Pipeline with GenomeScale
Computational Modeling of Microbial Communities
Drug Targeting of the Human Microbiome
Toward GenomeScale Models of Signal Transduction
Systems Biology of Aging
Modeling the Dynamics of the Immune Response
Dynamics of Signal Transduction in Single Cells Quantified
ImageBased In silico Models of Organogenesis
Progress toward Quantitative Design Principles of Multicellular
Precision Genome Editing for Systems Biology A Temporal
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