Nobel Prizes That Changed MedicineTony Seed, Gilbert Thompson, Jackie Downs and John MacDermot at the book's launch in LondonThis book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research.Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation's website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise./a |
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Inhalt
Chapter 2 The Discovery of the Cure for Pernicious Anaemia Vitamin B12 A Victor Hoffbrand | 21 |
Chapter 3 The Discovery of Penicillin Eric Sidebottom | 45 |
Chapter 4 The Introduction of Cardiac Catheterisation Tony Seed | 69 |
Chapter 5 The Discovery of the Structure of DNA James Scott and Gilbert Thompson | 89 |
Chapter 6 The Interpretation of the Genetic Code John MacDermot and Ellis Kempner | 113 |
Chapter 7 The Discovery of Neuropeptides and Radioimmunoassay of Peptide Hormones Jaimini Cegla and Stephen Bloom | 133 |
Chapter 8 The Development of ComputerAssisted Tomography Adrian M K Thomas | 151 |
Chapter 9 The Discovery of Prostaglandins Rod Flower | 171 |
Chapter 11 The Discovery of the LDL Receptor and Its Role in Cholesterol Metabolism Gilbert Thompson | 217 |
Chapter 12 The Invention of the Polymerase Chain Reaction and Use of SiteDirected Mutagenesis Anne K Soutar | 237 |
Chapter 13 The Discovery of the Pathophysiological Role of Nitric Oxide in Blood Vessels Keith M Channon | 263 |
Chapter 14 The Discovery of Helicobacter Pylori Chris Hawkey | 281 |
Chapter 15 The Discovery of RNA Interference Gene Silencing by DoubleStranded RNA Richard P Hull and Timothy J Aitman | 309 |
The First 100 Nobel Prizes in Physiology or Medicine | 329 |
335 | |
Chapter 10 The Antibody Problem and the Generation of Monoclonal Antibodies Herman Waldmann and Celia P Milstein | 197 |
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Acad Sci USA activity amino acid anaemia antibodies antigen arachidonic acid artery aspirin associated awarded bacteria Banting Barry Marshall became Biol biological blood cancer cardiac cells cholesterol clinical Cormack Cournand Crick diabetes discovery disease drugs dsRNA EDRF effects elegans endoperoxides enzyme extract factor Fleming Florey folate Furchgott gastric gene genome Godfrey Hounsfield Goldstein guanylate cyclase Guillemin Helicobacter pylori hormone Hospital Hounsfield human hypercholesterolaemia Ignarro inhibition injection insulin intentionally left blank isolated laboratory Lancet LDL receptor liver London Macleod Marshall mechanism Mello metabolism Milstein Minot molecular Mullis mutation Natl Acad Sci Nature Nirenberg nitric oxide Nobel Prize oligonucleotides Oxford paper patients penicillin peptide Physiology or Medicine plasma Prize in Physiology Proc Natl Acad Professor prostaglandin protein pulmonary RNA interference RNAi role Schally Science scientists sequence siRNA SNPs studies substance synthesis techniques therapeutic tion tissue treatment ulcer University vitamin B12 Watson X-ray Yalow