Immunohistochemical Comparison of Mononuclear Cell Populations in Diseases of the Canine Central Nervous System

Iowa State University, 2001 - 166 Seiten
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A total of 39 dogs with histopathologically confirmed central nervous system (CNS) mononuclear pleocytosis were characterized immunohistochemically using antibodies against CD3, lysozyme, canine immunoglobulin (IgG, IgM, IgA), canine distemper virus, Toxoplasma gondii, and Neospora caninum. Twenty-six dogs had lesions compatible with granulomatous meningoencephalomyelitis (GME), 6 with canine distemper, 1 with toxoplasmosis, 1 with neosporosis, 2 with CNS lesions of unknown cause, and 3 with spinal cord lymphoma. All dogs were evaluated immunohistochemically for distemper, toxoplasma and neospora antigens. The dogs ranged in age from 2 months to 14 years and the ratio of females to males was 2:1 with no breed predilection. CNS lesions consisted primarily of mononuclear perivascular and granulomatous parenchymal and meningeal infiltrates. In some cases, white and gray matter necrosis also were present. Macrophages and lymphocytes comprised the majority of the infiltrates; their numbers varied within and between the disease categories. Dogs with GME had primarily CD3 antigen positive T cells, as well as, lysozyme positive cells.

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