Generation of Antibodies by Cell and Gene Immortalization

Acad Sci USA adhesion adult T-cell leukemia affinity Albertini A eds amino acid analysis anti-CEA antibody anti-Tac Antibodies by Cell assay biMAb binding Biol bispecific bispecific monoclonal antibodies Boersma WJA Ca2+ Cancer carcinoma cDNA Cell and Gene cell line chromosome Claassen clinical clones coli conjugate constant region culture cytotoxic deletion detection effector ELISA epitope erythrocytes expression FdUMP function fusion Gene Immortalization genetic growth factor heavy chain human antibody hybrid hybridoma immune immunogenic immunoglobulin Immunol IOR C2 Karger keratinocytes leukemia light chain lymphocytes Malavasi F Methods mice MoAb molecular molecules monoclonal antibodies mouse murine mutant Natl Acad Sci oligonucleotide patients phage primers Proc Natl Acad production protein rodent scFv sequence signal peptide signal transduction specific structure supernatant surface synthetic peptides T-cell activation target TCR/CD3 complex Terhorst therapy tissue tumor cells vector virus vitro vivo XTUU