Managing Complexity, Reducing Perplexity: Modeling Biological SystemsMarcello Delitala, Giulia Ajmone Marsan Springer, 04.06.2014 - 133 Seiten ”Managing Complexity, Reducing Perplexity” is devoted to an overview of the status of the art in the study of complex systems, with particular focus on the analysis of systems pertaining to living matter. Both senior scientists and young researchers from diverse and prestigious institutions with a deliberately interdisciplinary cut were invited, in order to compare approaches and problems from different disciplines. The common aim of the contributions was to analyze the complexity of living systems by means of new mathematical paradigms that are more adherent to reality and which are able to generate both exploratory and predictive models that are capable of achieving a deeper insight into life science phenomena. |
Inhalt
| 1 | |
2 Quantitative Approaches to Heterogeneity and Growth Variability in Cell Populations | 15 |
The Impact of Phenotypic Switching | 28 |
From Signaling Pathway to Pattern Formation | 37 |
5 Multiscale Analysis and Modelling for Cancer Growth and Development | 45 |
6 A Nonlinear FluxLimited Model for the Transport of Morphogens | 54 |
A Phenomenon Shared by All Domains of Life | 65 |
8 Some Thoughts on the Ontogenesis in BCell Immune Networks | 71 |
9 Mathematical Modeling of Cancer Cells Evolution Under Targeted Chemotherapies | 80 |
10 Traveling Waves Emerging in a Diffusive Moving Filament System | 91 |
A Mathematical Model Describing the Chemotactic Migration of Hematopoietic Stem Cells | 100 |
A Useful Tool for the Artificial Pancreas | 109 |
An Introduction | 119 |
14 The Language of Systems Biology | 130 |
Häufige Begriffe und Wortgruppen
Ajmone Marsan eds alignment analysis angiogenesis bacteria behavior Biol cancer cells cancer invasion cancer modelling carbohydrate cell population cell-to-cell cellular chemotaxis clonal clones computational concentration cytoskeleton DDE models Delay Differential Equation Delitala and G described differential equations diffusion equations distribution dynamics e-mail ecology emerging evolution experimental filaments flux-limited function genes genotypic-phenotypic profiles glioma glucose glucose-insulin system Glycomics glycosylation heterogeneity Hillen HSCs insulin interactions International Publishing Switzerland ligand lymphocytes macroscopic Managing Complexity Math mathematical model Mathematics & Statistics mechanisms metastasis morphogen motility multiscale mutations parameters phenotypic switching problem Proceedings in Mathematics proliferation proteins Publishing Switzerland 2014 quenched disorder Reducing Perplexity scales sciences self-antigens signaling pathway simulations solutions Sonic Hedgehog spatial spin glass Springer International Publishing Springer Proceedings Statistics 67 stem cells stochastic stroma cells Systems Biology theory therapy three-scale convergent tissue traveling wave tumor variability velocity wave profiles