Computational Systems BiologyAndres Kriete, Roland Eils Elsevier, 10.11.2005 - 424 Seiten Systems Biology is concerned with the quantitative study of complex biosystems at the molecular, cellular, tissue, and systems scales. Its focus is on the function of the system as a whole, rather than on individual parts. This exciting new arena applies mathematical modeling and engineering methods to the study of biological systems. This book is the first of its kind to focus on the newly emerging field of systems biology with an emphasis on computational approaches. The work covers new concepts, methods for information storage, mining and knowledge extraction, reverse engineering of gene and metabolic networks, as well as modelling and simulation of multi-cellular systems. Central themes include strategies for predicting biological properties and methods for elucidating structure-function relationships. |
Inhalt
1 | |
15 | |
3 Natural Language Processing and Ontologyenhanced Biomedical Literature Mining for Systems Biology | 39 |
4 Integrated Imaging Informatics | 57 |
A Computational Systems Biology Tool within the Valis Bioinformatics Environment | 79 |
6 Standards Platforms and Applications | 103 |
7 Introduction to Computational Models of Biochemical Reaction Networks | 127 |
8 Biological Foundations of Signal Transduction and the Systems Biology Perspective | 149 |
Estimation Modeling and Simulation | 205 |
12 A Discrete Approach to TopDown Modeling of Biochemical Networks | 229 |
Deterministic Versus Stochastic Approaches | 249 |
Cell Fates as Highdimensional Attractors of Gene Regulatory Networks | 293 |
15 SpatioTemporal Systems Biology | 327 |
16 Cytomicsfrom Cell States to Predictive Medicine | 363 |
Progress and Plans | 383 |
395 | |
9 Reconstruction of Metabolic Network from Genome Information and Its Structural and Functional Analysis | 169 |
10 Integrated Regulatory and Metabolic Models | 191 |
Andere Ausgaben - Alle anzeigen
Computational Systems Biology: From Molecular Mechanisms to Disease Andres Kriete,Roland Eils Eingeschränkte Leseprobe - 2013 |
Computational Systems Biology: From Molecular Mechanisms to Disease Andres Kriete,Roland Eils Keine Leseprobe verfügbar - 2013 |
Häufige Begriffe und Wortgruppen
activation algorithm analysis approach attractor Bayesian networks behavior biochemical networks Bioinformatics Biol biological systems biomedical BMAL1 Boolean networks cell fate CellML CellSim cellular circadian clock circadian oscillations circadian rhythms clustering coli complex components computational systems biology concentration cytomics cytosol database defined described deterministic developed discrete domain Drosophila dynamics enzyme example experiments expression profiles flux function gene expression gene networks Gene Regulatory Networks genetic genome Gonze graph high-throughput integration interactions Kholodenko kinase kinetic mathematical models matrix mechanism metabolic networks metabolites methods microarray data model for circadian modules molecules mRNA network model optimal organisms parameters patterns PER-TIM perturbations Petri net phase phenotypes phosphorylation Physiome predicted processes protein proteomics quantitative receptor regulation represent SBML shown in Figure signal transduction signaling pathways silico Simpathica simulation specific step stochastic structure tion tissue transcription transcription factors Valis values variables Westerhoff
Beliebte Passagen
Seite x - Science is built up with facts, as a house is with stones. But a collection of facts is no more a science than a heap of stones is a house.
Seite 34 - Brazma A. Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege...
Seite 34 - Brazma A, Parkinson H, Sarkans U, Shojatalab M, Vilo J, Abeygunawardena N, Holloway E, Kapushesky M, Kemmeren P, Lara GG, Oezcimen A, Rocca-Serra P, Sansone SA (2003).
Seite 35 - Hubbard, T., Barker, D., Birney, E., Cameron, G., Chen, Y., Clark, L., Cox, T., Cuff, J., Curwen, V., Down, T., Durbin, R., Eyras, E., Gilbert, J., Hammond, M., Huminiecki, L., Kasprzyk, A., Lehvaslaiho, H., Lijnzaad, P., Melsopp, C., Mongin, E., Pettett, R., Pocock, M., Potter, S., Rust, A., Schmidt, E., Searle, S., Slater, G., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Stupka, E., UretaVidal, A., Vastrik, I., and Clamp, M.
Seite 34 - McVicker, G., Melsopp, C., Meidl, P., Potter, S., Proctor, G., Rae, M., Rios, D., Schuster, M., Searle, S., Severin, J., Slater, G., Smedley, D., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Storey, R., Trevanion, S., Ureta-Vidal, A., Vogel, J., White, S., Woodwark, C., Birney, E.
Verweise auf dieses Buch
Risk Assessment for Environmental Health Mark G. Robson,William A. Toscano Eingeschränkte Leseprobe - 2007 |
Systems Biology: Philosophical Foundations Fred Boogerd,Frank J. Bruggeman,Jan-Hendrik S. Hofmeyr,H.V. Westerhoff Eingeschränkte Leseprobe - 2007 |