Catalysis in Chemistry and EnzymologyCourier Corporation, 01.01.1987 - 836 Seiten Exceptionally clear, carefully written treatment of the nature of catalysis of reactions in aqueous solution. Coverage of mechanisms for catalysis, forces in aqueous solution, carbonyl- and acyl-group reactions, practical kinetics, and much more. Extensive bibliography. "... a masterpiece."—Nature. |
Inhalt
MECHANISMS FOR CATALYSIS | 7 |
Covalent Catalysis | 42 |
Observation of the formation and disappearance of an intermediate | 45 |
Decomposition at the same rate of a common intermediate formed from different substrates | 50 |
Partitioning of the intermediate to give two products at a constant total rate | 53 |
Partitioning of a common intermediate to a constant ratio of two products | 56 |
Exchange and transfer reactions | 60 |
Exchange and inhibition | 64 |
ATP and metals | 112 |
Decarboxylation of Bketo acids | 116 |
Aldol condensations | 120 |
Thiamine pyrophosphate | 127 |
Pyridoxal | 133 |
Other examples | 146 |
F Oxidative Catalysis | 150 |
G Oxidative Activation | 154 |
Nucleophilic Catalysis | 67 |
Nucleophilic groups in enzymes | 71 |
Carbonyl transfer reactions | 72 |
cistrans Isomerization | 74 |
Phosphate transfer | 76 |
Alkyl transfer | 77 |
Nucleophilic Reactivity | 78 |
Basicity | 79 |
Polarizability oxidationreduction potential softness | 85 |
Solvation | 92 |
Steric hindrance | 96 |
Electrostatic effects | 97 |
Resonance stabilization and structural rearrangements | 98 |
Bond strength to carbon | 99 |
Intramolecular general acid catalysis | 103 |
The a effect | 107 |
E Electrophilic Catalysis | 111 |
General AcidBase Catalysis | 163 |
Other examples | 168 |
B The Brønsted Relationship | 178 |
Isotope Effects | 243 |
Strain Distortion and Conformation Change | 282 |
FORCES IN AQUEOUS SOLUTION | 321 |
Electrostatic Interactions | 351 |
Hydrophobic Forces | 393 |
DonorAcceptor and Charge Transfer Interactions | 437 |
PART III | 460 |
RCSR and H₂NR | 537 |
Practical Kinetics | 555 |
B The Utilization of Pseudo Firstorder Rate Constants | 568 |
APPENDIX | 615 |
| 807 | |
| 823 | |
Andere Ausgaben - Alle anzeigen
Häufige Begriffe und Wortgruppen
acceptor acetate acid catalysis active site acyl addition intermediate aldehyde amine aminolysis anion aqueous solution attack base catalysis basicity binding energy Biol carbon carbonyl group catalyzed reaction cationic charge transfer Chem complex compounds concentration conformation change covalent decrease destabilization deuterium dissociation driving force electron electrostatic enthalpy entropy enzyme enzyme-substrate equilibrium constant ester example experimental factor favorable formation free energy H₂O hydration hydrogen bonding hydrolysis hydrophobic hydroxide ion hydroxyl group imidazole increase interaction intramolecular reaction involves ionic ionization isotope effect k₁ k₂ kcal/mole kinetic leaving group methyl micelle nonpolar nucleophilic observed rate occur oxide peptide phenyl phosphate Phys protein proton proton transfer rate acceleration rate constant rate law rate-determining step reactants reacting groups reactivity relative salts solvation solvent specific stabilization starting materials structure substituents substrate tetrahedral thiol tion transition undergo utilized W. P. Jencks water molecules
Verweise auf dieses Buch
Chemical Kinetics: The Study of Reaction Rates in Solution Kenneth Antonio Connors Eingeschränkte Leseprobe - 1990 |